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Piipari R et al

doi: 10.1038/s41591-019-0405-7 265

Cryptorchidism, or undescended testes, in which one or both testicles fail to descend into the scrotum, is the most common birth defect of male genitalia

Similarly, in male mice, a biogenic immune stressor producing sustained IFN- elevations induced chronic increases in both peripheral and brain IDO activity, accompanied by widespread TRP depletion, indicating that prolonged cytokine signalling drives central and peripheral TRP loss [68]

found that increased GPx1 levels significantly increased the resistance of breast cancer T47D cells to doxorubicin partially by interfering with the activation of the sphingomyelin-ceramide pathway [85]